The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors
| Autoři | |
|---|---|
| Rok publikování | 2014 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | British Journal of Haematology |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://onlinelibrary.wiley.com/doi/10.1111/bjh.12893/abstract |
| Doi | https://doi.org/10.1111/bjh.12893 |
| Obor | Onkologie a hematologie |
| Klíčová slova | chronic lymphocytic leukaemia; immunoglobulin genes; stereotyped B cell receptors; TP53 mutations; prognosis |
| Přiložené soubory | |
| Popis | In chronic lymphocytic leukaemia (CLL) tumour initiation and progression are linked to the interplay between cellextrinsic and cell-intrinsic mechanisms. Cell-extrinsic mechanisms relate to the crosstalk of CLL cells with their microenvironment through various receptors, including the B-cell receptor (BcR). |
| Související projekty: |
|