The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors

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Authors

MALČÍKOVÁ Jitka STALIKA Evangelia DAVIS Zadie PLEVOVÁ Karla TRBUŠEK Martin MANSOURI Larry SCARFO Lydia BALIAKAS Panagiotis GARDINER Anne SUTTON LA FRANCOVA Hana Skuhrová AGATHANGELIDIS Andreas ANAGNOSTOPOULOS Achilles TRACY Ian MAKRIS Antonis ŠMARDOVÁ Jana GHIA Paolo BELESSI Chrysoula GONZALEZ David ROSENQUIST Richard OSCIER David POSPÍŠILOVÁ Šárka STAMATOPOULOS Kostas

Year of publication 2014
Type Article in Periodical
Magazine / Source British Journal of Haematology
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://onlinelibrary.wiley.com/doi/10.1111/bjh.12893/abstract
Doi http://dx.doi.org/10.1111/bjh.12893
Field Oncology and hematology
Keywords chronic lymphocytic leukaemia; immunoglobulin genes; stereotyped B cell receptors; TP53 mutations; prognosis
Attached files
Description In chronic lymphocytic leukaemia (CLL) tumour initiation and progression are linked to the interplay between cellextrinsic and cell-intrinsic mechanisms. Cell-extrinsic mechanisms relate to the crosstalk of CLL cells with their microenvironment through various receptors, including the B-cell receptor (BcR).
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