Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties

Varování

Publikace nespadá pod Ústav výpočetní techniky, ale pod Farmaceutickou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	MALANÍK Milan TREML Jakub KUBÍNOVÁ Renata VÁVROVÁ Gabriela ORAVEC Michal MAREK Jaromír ZHAPARKULOVA Karlygash ŠMEJKAL Karel
Rok publikování	2025
Druh	Další prezentace na konferencích
Fakulta / Pracoviště MU	Farmaceutická fakulta
Citace
Popis	Extensive chromatographic separation of a chloroform-soluble fraction led to the isolation of twenty compounds, including a unique monoterpene diperoxy dimer (1). The structures were elucidated by 1D and 2D NMR experiments along with HRMS. Compound 1 was additionally identified by the single crystal X-ray diffraction method. ?-Glucosidase inhibitory assay and GLUT4 expression and translocation in C2C12 myotubes were conducted to evaluate antidiabetic potential of selected compounds (1–11). Compounds 7 and 9–11 displayed more potent ?-glucosidase inhibitory activity (IC50 45.3–135.3 µM) than acarbose used as a positive control (IC50 264.7 µM), while only pomolic acid (5) increased GLUT4 translocation in C2C12 myotubes in a significant manner.
Související projekty:	Role prenylace a glykosylace v protizánětlivé aktivitě a metabolismu přírodních fenolových látek