Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties
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| Year of publication | 2025 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | Extensive chromatographic separation of a chloroform-soluble fraction led to the isolation of twenty compounds, including a unique monoterpene diperoxy dimer (1). The structures were elucidated by 1D and 2D NMR experiments along with HRMS. Compound 1 was additionally identified by the single crystal X-ray diffraction method. ?-Glucosidase inhibitory assay and GLUT4 expression and translocation in C2C12 myotubes were conducted to evaluate antidiabetic potential of selected compounds (1–11). Compounds 7 and 9–11 displayed more potent ?-glucosidase inhibitory activity (IC50 45.3–135.3 µM) than acarbose used as a positive control (IC50 264.7 µM), while only pomolic acid (5) increased GLUT4 translocation in C2C12 myotubes in a significant manner. |
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