Translational Value of Proton MRS in Depression: Applications to Preclinical Models
| Název česky | Translační význam protonové MRS u deprese: Aplikace na preklinické modely |
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| Autoři | |
| Rok publikování | 2025 |
| Druh | Kapitola v knize |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | This chapter compares the consistent 1H MRS evidence from the animal models to the clinical findings. The clinical results largely correspond to the animal studies in the prefrontal cortex, where the higher choline and lower glutamax (glutamate+glutamine) levels are reported. This marker indicates cell membrane turnover and neuronal metabolism dysfunction. The hippocampus in MDD patients is understudied in the clinical field making an assessment of consistency of preclinical and clinical findings impossible. Use of 1H MRS method provides new insights into neuro-molecular process in MDD and has a potential to become a useful biomarker for tracking the success of treatment interventions in MDD. |
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