Biomimetic antimicrobial polymers-Design, characterization, antimicrobial, and novel applications

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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TAKAHASHI Haruko SOVADINOVÁ Iva YASUHARA Kazuma VEMPARALA Satyavani CAPUTO Gregory A. KURODA Kenichi

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://wires.onlinelibrary.wiley.com/doi/10.1002/wnan.1866
Doi http://dx.doi.org/10.1002/wnan.1866
Klíčová slova antimicrobial polymers; cancer; cyanobacteria; liposome; simulations
Přiložené soubory
Popis Biomimetic antimicrobial polymers have been an area of great interest as the need for novel antimicrobial compounds grows due to the development of resistance. These polymers were designed and developed to mimic naturally occurring antimicrobial peptides in both physicochemical composition and mechanism of action. These antimicrobial peptide mimetic polymers have been extensively investigated using chemical, biophysical, microbiological, and computational approaches to gain a deeper understanding of the molecular interactions that drive function. These studies have helped inform SARs, mechanism of action, and general physicochemical factors that influence the activity and properties of antimicrobial polymers. However, there are still lingering questions in this field regarding 3D structural patterning, bioavailability, and applicability to alternative targets. In this review, we present a perspective on the development and characterization of several antimicrobial polymers and discuss novel applications of these molecules emerging in the field. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease
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