SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Farmaceutickou fakultu. Oficiální stránka publikace je na webu muni.cz.
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BALLAYOVÁ Veronika KAUEROVÁ Tereza KOLLÁR Peter FARSA Oldřich

Rok publikování 2023
Druh Další prezentace na konferencích
Fakulta / Pracoviště MU

Farmaceutická fakulta

Citace
Popis Basic thiosemicarbazone and semicarbazone derivatives of acetophenone with imine functional group belong to the group commonly called Schiff bases. Therapeutics and compounds belonging to this group are versatile pharmacophores with a significant capability of forming chelates with various metal ions. Such metal complexes play an important role in therapeutics due to their remarkable broad-spectrum of biological activities. Due to the above-mentioned complex formation, many Schiff bases appear as an important intermediate in a number of enzymatic reactions. One of the possible target enzyme is a neutral zinc-binding metalloenzyme aminopeptidase N (AP-N), also called membrane alanyl aminopeptidase. Potential inhibitors of this omnipresent enzyme may offer effective and broad-spectrum therapy. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.
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