Merging the exposome into an integrated framework for "omics" sciences

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

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PRICE Elliott James VITALE Chiara Maria MILLER Gary W. DAVID Arthur BAROUKI Robert AUDOUZE Karine WALKER Douglas I. ANTIGNAC Jean-Philippe COUMOUL Xavier BESSONNEAU Vincent KLÁNOVÁ Jana

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj iSCIENCE
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S2589004222002462?via%3Dihub
Doi http://dx.doi.org/10.1016/j.isci.2022.103976
Klíčová slova SYSTEMS BIOLOGY; EXPOSURE SCIENCE; HEALTH; ENVIRONMENT; DETERMINANTS; MIXTURES; DYNAMICS; IMPACTS; DISEASE; TIME
Přiložené soubory
Popis The exposome concept encourages holistic consideration of the non-genetic factors (environmental exposures including lifestyle) that influence an individual's health over their life course. However, disconnect between the concept and practical application has promoted divergent interpretations of the exposome across disciplines and reinforced separation of the environmental (emphasizing exposures) and biological (emphasizing responses) research communities. In particular, while knowledge of biological responses can help to distinguish actual (i. e. experienced) from potential exposures, the inclusion of endogenous processes has generated confusion about the position of the exposome in a multi-omics systems biology context. We propose a reattribution of "exposome'' to exclusively represent the totality of contact with external factors that a biological entity experiences, and introduce the term "functional exposomics'' to denote the systematic study of exposure-phenotype interaction. This reoriented definition of the exposome allows a more readily integrable dataset for multiomics and systems biology research.
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