Analysis of B-Cell Subpopulations in Monoclonal Gammopathies
| Autoři | |
|---|---|
| Rok publikování | 2015 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Clinical Lymphoma Myeloma & Leukemia |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | https://doi.org/10.1016/j.clml.2014.12.003 |
| Obor | Onkologie a hematologie |
| Klíčová slova | B-cell; Flow Cytometry; Multiple Myeloma; Monoclonal Gammopathy; Plasma Cell |
| Popis | To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and differentiation shift to more numerous antigenstimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations. |
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