Analysis of B-Cell Subpopulations in Monoclonal Gammopathies

• Authors: VŠIANSKÁ Pavla; ŘÍHOVÁ Lucie; VARMUŽOVÁ Tamara; SUSKÁ Renata; KRYUKOV Fedor; MIKULÁŠOVÁ Aneta; KUPSKÁ Renata; PENKA Miroslav; POUR Luděk; ADAM Zdeněk; HÁJEK Roman
• Year of publication: 2015
• Type: Article in Periodical
• Magazine / Source: Clinical Lymphoma Myeloma & Leukemia
• MU Faculty or unit: Faculty of Medicine
• Doi: https://doi.org/10.1016/j.clml.2014.12.003
• Field: Oncology and hematology
• Keywords: B-cell; Flow Cytometry; Multiple Myeloma; Monoclonal Gammopathy; Plasma Cell
• Description: To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and differentiation shift to more numerous antigenstimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations.

Related projects

• From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
• Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií