Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 313
2020
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Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition
Nucleic acids research, rok: 2020, ročník: 48, vydání: 4, DOI
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Stereocontrolled Synthesis of (-)-Bactobolin A
Journal of the American Chemical Society, rok: 2020, ročník: 142, vydání: 16, DOI
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Surface design of photon-upconversion nanoparticles for high-contrast immunocytochemistry
Nanoscale, rok: 2020, ročník: 12, vydání: 15, DOI
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Thermal properties of Ag@Ni core-shell nanoparticles
Computer Coupling of Phase Diagrams and Thermochemistry, rok: 2020, ročník: 69, vydání: JUN 2020, DOI
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Transgelin Silencing Induces Different Processes in Different Breast Cancer Cell Lines
Proteomics, rok: 2020, ročník: 20, vydání: 7, DOI
2019
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#CEITEC100 Alumni Day
Rok: 2019, druh: Popularizační texty
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#CEITEC100 Open Day
Rok: 2019, druh: Popularizační texty
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A novel Kunitz protein with proposed dual function from Eudiplozoon nipponicum (Monogenea) impairs haemostasis and action of complement in vitro
International Journal for Parasitology, rok: 2019, ročník: 49, vydání: 5, DOI
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A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling
Nucleic acids research, rok: 2019, ročník: 47, vydání: 16, DOI
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Activity of N-Phenylpiperazine Derivatives Against Bacterial and Fungal Pathogens
CURRENT PROTEIN & PEPTIDE SCIENCE, rok: 2019, ročník: 20, vydání: 11, DOI