Base pair stacking in nucleosome DNA and bendability sequence pattern
| Autoři | |
|---|---|
| Rok publikování | 2010 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | JOURNAL OF THEORETICAL BIOLOGY |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Genetika a molekulární biologie |
| Klíčová slova | Chromatin; Chromatin code; DNA deformation; DNA minor grooves; Nucleosome DNA sequence; Nucleosome positioning |
| Popis | DNA deformation in the nucleosome involves partial unstacking between bases and base pairs. By adjusting orientations of different base-pair stacks relative to the histone octamer surface, the optimal set of stacks and their positions is derived, resulting in a sequence pattern, theoretically best suitable for nucleosome DNA. The sequence is very much consistent with available experimental data, thus, suggesting a common eukaryotic nucleosome DNA bendability sequence pattern based exclusively on the very basics of DNA. (C) 2009 Elsevier Ltd. All rights reserved. |
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