CORD: Comparison of Recommended Doses of ace inhibitors and angiotensin II receptor blockers
| Autoři | |
|---|---|
| Rok publikování | 2009 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | International Journal of Cardiology |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Kardiovaskulární nemoci včetně kardiochirurgie |
| Klíčová slova | Hypertension; Losartan; Ramipril; Cough |
| Popis | The CORD trials tested ramipril and losartan in patients with hypertension. CORD A randomised 4016 patients with blood pressure (BP) < 160/100 mm Hg, who had been treated with an ACEI for > 3 months. The patients discontinued ACEI and switched to losartan. After 1 month the BP decreased to 7.7/4.7 mm Hg (p < 0.001) and after 1 year to 13.8/8.7 mm Hg (p < 0.001). CORD B compared ramipril and losartan in 3813 patients with hypertension who were not being treated with an ACEI or ARB. The patients were randomised to ramipril (n = 1926) or losartan (n = 1887). After 1 year the BP decreased in the ramipril group to 21.8/13.7 mm Hg (p < 0.001) and in the losartan group to 22.0/13.3 mm Hg (p < 0.001). No significant differences were found between the groups. No differences were in serious adverse events. Dry cough was more frequently after ramipril (33 vs 4, p < 0.001). |
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