Reversibility of cadmium-induced apoptosis is associated with increased level of telomerase activity in tobacco TBY-2 cells

Varování

Publikace nespadá pod Ústav výpočetní techniky, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	FOJTOVÁ Miloslava FULNEČKOVÁ Jana FAJKUS Jiří KOVAŘÍK Aleš
Rok publikování	2001
Druh	Článek ve sborníku
Konference	Journal of Biomolecular Structure and Dynamics
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Obor	Biofyzika
Klíčová slova	cadmium-induced apoptosis; tobacco
Popis	To monitor apoptotic changes, we followed several parameters including cell viability, DNA integrity and telomerase activity.Preapoptotic phase has been achieved by exposure of cells to 50mM cadmium for 3 days.At that time the cell culture retains more than 95% viability although the majority of DNA is fragmented into 50-200 kb.Integrity of DNA is reestablished within two days after cadmium removal suggesting that an efficient DNA repair process has occurred.In parallel, a significant increase of telomerase activity in cell extracts is observed.The data suggest an involvement of telomerase in plant chromosome healing in response to damage caused by genotoxic agents.
Související projekty:	Genomy a jejich funkce