Functional replacements in nerve tissue regeneration, an in vitro study
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| Rok publikování | 2025 |
| Druh | Konferenční abstrakty |
| Citace | |
| Popis | Injuries to the sciatic nerve present a profound therapeutic challenge, often resulting in significant motor and sensory deficits and a reduced quality of life. Advances in 3D printing technology have enabled the development of scaffolds that closely replicate the native architecture of peripheral nerve tissue, offering new possibilities for nerve regeneration. Schwann cells play a pivotal role in this process by supporting axonal regrowth and facilitating myelination. This study explores printable, polymer-based biocompatible materials designed to support Schwann cell adhesion, viability, and differentiation in vitro. Immunocytochemical staining for ß-actin was used to assess cell morphology and the extension of cellular processes. Different biomaterials and fabrication patterns were systematically evaluated to identify optimal conditions for enhancing cell proliferation and neurite-like process outgrowth. The enhanced composite scaffolds demonstrated superior performance, supporting robust Schwann cell growth and structural development. These findings provide a promising basis for the design of advanced scaffold-based conduits in peripheral nerve tissue engineering. |
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