Noninvasive Temporal Interference Stimulation of the Subthalamic Nucleus in Parkinson's Disease Reduces Beta Activity

Logo poskytovatele

Varování

Publikace nespadá pod Ústav výpočetní techniky, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
Autoři

LAMOŠ Martin BOČKOVÁ Martina MISSEY Florian LUBRANO Claudia DE ARAUJO E SILVA Mariane TRAJLINEK Jan STUDNICKA Ondrej DANIEL Pavel CARRON Romain JIRSA Viktor CHRASTINA Jan JANČÁLEK Radim GLOWACKI Eric Daniel CASSARA Antonino NEUFELD Esra REKTOROVÁ Irena WILLIAMSON Adam

Rok publikování 2025
Druh Článek v odborném periodiku
Časopis / Zdroj Movement Disorders
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.30134
Doi http://dx.doi.org/10.1002/mds.30134
Klíčová slova temporal interference stimulation; deep brain stimulation; subthalamic nucleus; Parkinson's disease; beta power; local field potentials
Přiložené soubory
Popis Background: Temporal interference stimulation (TIS) is a novel noninvasive electrical stimulation technique to focally modulate deep brain regions; a minimum of two high-frequency signals (f(1) and f(2) > 1 kHz) interfere to create an envelope-modulated signal at a deep brain target with the frequency of modulation equal to the difference frequency: Delta f = |f(2) - f(1)|. Objective: The goals of this study were to verify the capability of TIS to modulate the subthalamic nucleus (STN) with Delta f and to compare the effect of TIS and conventional deep brain stimulation (DBS) on the STN beta oscillations in patients with Parkinson's disease (PD). Methods: DBS leads remained externalized after implantation, allowing local field potentials (LFPs) recordings in eight patients with PD. TIS was performed initially by two pairs (f(1) = 9.00 kHz; f(2) = 9.13 kHz, 4 mA peak-peak per pair maximum) of scalp electrodes placed in temporoparietal regions to focus the envelope signal maximum (Delta f = 130 Hz) at the motor part of the STN target. Results: The comparison between the baseline LFPs and recordings after TIS and conventional DBS sessions showed substantial suppression of high beta power peak after both types of stimulation in all patients. Conclusions: TIS has the potential to effectively modulate the STN and reduce the beta oscillatory activity in a completely noninvasive manner, as is traditionally possible only with intracranial DBS. Future studies should confirm the clinical effectiveness of TIS and determine whether TIS could be used to identify optimal DBS candidates and individualize DBS targets. (c) 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info