Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content

• Autoři: TORRISI Jacopo; CHVOJKA Matúš; JURČEK Pia Yasmine; ZHANG Xinxin; ZENG Huaqiang; ŠINDELÁŘ Vladimír; VALKENIER Hennie
• Rok publikování: 2025
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Angewandte Chemie International Edition
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: https://onlinelibrary.wiley.com/doi/10.1002/anie.202424754
• Doi: https://doi.org/10.1002/anie.202424754
• Klíčová slova: Supramolecular Chemistry; Anion transport; Anion Channels; Macrocycles; Bambusurils

Přiložené soubory

• 2483224.pdf

• Popis: Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.

Související projekty

• CETOCOEN Excellence
• Czech Infrastructure for Integrative Structural Biology
• Chemická modifikace bambusurilů pro úpravu jejich vazebné afinity a selektivity
• Výzkumná infrastruktura RECETOX