Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

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GOMEZ PEREZ Inmaculada Jennifer RUSSO Marina ARCIDIACONO Orazio Angelo MARQUEZ SANCHEZ - CARNERERO Esther Maria KLÁN Petr ZAJÍČKOVÁ Lenka

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Materials Chemistry Frontiers
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K
Doi http://dx.doi.org/10.1039/d2qm00200k
Klíčová slova SINGLET OXYGEN GENERATION; PHOTODYNAMIC THERAPY; CARBON DOTS; NANOPARTICLES; DERIVATIVES; MECHANISMS; MOLECULES
Popis The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation.
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