Complexes of NOTA-Monoamides with CuII Ions: Structural, Equilibrium, and Kinetic Study

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

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KUBINEC Jan ŠIRŮČKOVÁ Viktorie HAVLÍČKOVÁ Jana KOTEK Jan KUBÍČEK Vojtěch LUBAL Přemysl HERMANN Petr

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj European Journal of Inorganic Chemistry
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejic.202200173
Popis NOTA monoamides are commonly and widely used chelators for the complexation of copper radioisotopes applied in molecular imaging and targeted nuclear therapy. However, information about their coordination behavior remains scarce. In this study, two NOTA-monoamides, N-ethyl (H2L1) and N,N-diethyl (H2L2), were synthesized as model ligands and tested to probe differences in their coordination behavior between the secondary and tertiary amide pendant arms for potential applications as copper radioisotope carriers. Our results demonstrated that the solid [Cu(L1)] and [Cu(L2)] complex have a distorted octahedral arrangement, similar to structure of the [Cu(Hnota)] complex. As shown by equilibrium data, the ligands have a slightly lower basicity, and thus complexes with divalent metal ions and LiI have slightly lower stability constants than those of the parent ligand, H3nota. The dissociation constants of the CuII, ZnII and NiII complexes with H2L1 also indicate deprotonation and N-coordination of the secondary amide group at pH>9. Complexation of CuII ions with the title ligands is slower than that with H3nota but still very fast (quantitative binding in <1 s, pH 2, millimolar concentrations), and CuII complexes of both monoamide ligands are more resistant to acid-assisted decomplexation than the CuII-H3nota complex. Therefore, our coordination data highlight that NOTA-monoamides are suitable chelators for molecular imaging and nuclear medicine.
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