FireProt(ASR): A Web Server for Fully Automated Ancestral Sequence Reconstruction

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

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MUSIL Miloš KHAN Rayyan Tariq BEIER Andy ŠTOURAČ Jan KONEGGER Hannes DAMBORSKÝ Jiří BEDNÁŘ David

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Briefings in Bioinformatics
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://academic.oup.com/bib/article/22/4/bbaa337/6042664
Doi http://dx.doi.org/10.1093/bib/bbaa337
Klíčová slova ancestral sequence reconstruction; ancestral enzymes; evolution; phylogeny-based analysis; protein stability
Přiložené soubory
Popis There is a great interest in increasing proteins' stability to widen their usability in numerous biomedical and biotechnological applications. However, native proteins cannot usually withstand the harsh industrial environment, since they are evolved to function under mild conditions. Ancestral sequence reconstruction is a well-established method for deducing the evolutionary history of genes. Besides its applicability to discover the most probable evolutionary ancestors of the modern proteins, ancestral sequence reconstruction has proven to be a useful approach for the design of highly stable proteins. Recently, several computational tools were developed, which make the ancestral reconstruction algorithms accessible to the community, while leaving the most crucial steps of the preparation of the input data on users' side. FireProt(ASR) aims to overcome this obstacle by constructing a fully automated workflow, allowing even the unexperienced users to obtain ancestral sequences based on a sequence query as the only input.
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