Alterations in Sensorimotor and Mesiotemporal Cortices and Diffuse White Matter Changes in Primary Progressive Multiple Sclerosis Detected by Adiabatic Relaxometry

Varování

Publikace nespadá pod Ústav výpočetní techniky, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
Autoři

FILIP Pavel DUFEK Michal MANGIA Silvia MICHAELI Shalom BAREŠ Martin SCHWARZ Daniel REKTOR Ivan VOJTÍŠEK Lubomír

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Frontiers in Neuroscience
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.frontiersin.org/articles/10.3389/fnins.2021.711067/full
Doi http://dx.doi.org/10.3389/fnins.2021.711067
Klíčová slova primary progressive multiple sclerosis; T1 mapping; T2 mapping; diffusion weighted imaging; DWI; adiabatic T1 rho mapping; adiabatic T2 rho mapping
Popis Background: The research of primary progressive multiple sclerosis (PPMS) has not been able to capitalize on recent progresses in advanced magnetic resonance imaging (MRI) protocols.

Objective: The presented cross-sectional study evaluated the utility of four different MRI relaxation metrics and diffusion-weighted imaging in PPMS.

Methods: Conventional free precession T1 and T2, and rotating frame adiabatic T1 rho and T2 rho in combination with diffusion-weighted parameters were acquired in 13 PPMS patients and 13 age- and sex-matched controls.

Results: T1 rho, a marker of crucial relevance for PPMS due to its sensitivity to neuronal loss, revealed large-scale changes in mesiotemporal structures, the sensorimotor cortex, and the cingulate, in combination with diffuse alterations in the white matter and cerebellum. T2 rho, particularly sensitive to local tissue background gradients and thus an indicator of iron accumulation, concurred with similar topography of damage, but of lower extent. Moreover, these adiabatic protocols outperformed both conventional T1 and T2 maps and diffusion tensor/kurtosis approaches, methods previously used in the MRI research of PPMS.

Conclusion: This study introduces adiabatic T1 rho and T2 rho as elegant markers confirming large-scale cortical gray matter, cerebellar, and white matter alterations in PPMS invisible to other in vivo biomarkers.

Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info