Virion structures and genome delivery of honeybee viruses

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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PROCHÁZKOVÁ Michaela ŠKUBNÍK Karel FÜZIK Tibor MUKHAMEDOVA Liya PRIDAL A. PLEVKA Pavel

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj CURRENT OPINION IN VIROLOGY
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.sciencedirect.com/science/article/pii/S1879625720300390?via%3Dihub
Doi http://dx.doi.org/10.1016/j.coviro.2020.06.007
Klíčová slova DEFORMED WING VIRUS; BEE PARALYSIS VIRUS; PICORNA-LIKE VIRUS; APIS-MELLIFERA L.; IN-VITRO; IDENTIFICATION; DECLINES; TRANSMISSION; PARTICLES; SACBROOD
Popis The western honeybee is the primary pollinator of numerous food crops. Furthermore, honeybees are essential for ecosystem stability by sustaining the diversity and abundance of wild flowering plants. However, the worldwide population of honeybees is under pressure from environmental stress and pathogens. Viruses from the families Iflaviridae and Dicistroviridae, together with their vector, the parasitic mite Varroa destructor, are the major threat to the world's honeybees. Dicistroviruses and iflaviruses have capsids with icosahedral symmetries. Acidic pH triggers the genome release of both dicistroviruses and iflaviruses. The capsids of iflaviruses expand, whereas those of dicistroviruses remain compact until the genome release. Furthermore, dicistroviruses use inner capsid proteins, whereas iflaviruses employ protruding domains or minor capsid proteins from the virion surface to penetrate membranes and deliver their genomes into the cell cytoplasm. The structural characterization of the infection process opens up possibilities for the development of antiviral compounds.
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