Detection of Chloroalkanes by Surface-Enhanced Raman Spectroscopy in Microfluidic Chips

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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PILAT Z. KIZOVSKY M. JEZEK J. KRATKY S. SOBOTA J. ŠILER Martin SAMEK O. BURYŠKA Tomáš VAŇÁČEK Pavel DAMBORSKÝ Jiří PROKOP Zbyněk ZEMANEK P.

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Sensors
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://loschmidt.chemi.muni.cz/peg/wp-content/uploads/2018/09/sensors-18-03212.pdf
Doi http://dx.doi.org/10.3390/s18103212
Klíčová slova surface enhanced Raman spectroscopy; microfluidics; Klarite 312; chloroalkane; 1; 2; 3-trichloropropane
Popis Optofluidics, a research discipline combining optics with microfluidics, currently aspires to revolutionize the analysis of biological and chemical samples, e.g., for medicine, pharmacology, or molecular biology. In order to detect low concentrations of analytes in water, we have developed an optofluidic device containing a nanostructured substrate for surface enhanced Raman spectroscopy (SERS). The geometry of the gold surface allows localized plasmon oscillations to give rise to the SERS effect, in which the Raman spectral lines are intensified by the interaction of the plasmonic field with the electrons in the molecular bonds. The SERS substrate was enclosed in a microfluidic system, which allowed transport and precise mixing of the analyzed fluids, while preventing contamination or abrasion of the highly sensitive substrate. To illustrate its practical use, we employed the device for quantitative detection of persistent environmental pollutant 1,2,3-trichloropropane in water in submillimolar concentrations. The developed sensor allows fast and simple quantification of halogenated compounds and it will contribute towards the environmental monitoring and enzymology experiments with engineered haloalkane dehalogenase enzymes.
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