Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats
| Název česky | Ketamin i NBQX potlačují pití alkoholu u potkaních samců kmene Wistar |
|---|---|
| Autoři | |
| Rok publikování | 2018 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Neuroscience Letters |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://www.sciencedirect.com/science/article/pii/S030439401731025X |
| Doi | https://doi.org/10.1016/j.neulet.2017.12.055 |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | Alcoholism; Alcohol use disorder; Glutamatergic receptors; NMDA receptor; AMPA receptor; Kainate receptor |
| Popis | Highlights: Acute low dose ketamine reduced alcohol intake but not alcohol-related behavioural effects. Acute low dose NBQX reduced alcohol intake but not alcohol-related behavioural effects. NMDA or AMPA/kainate receptor antagonists may have treatment potential in alcohol use disorder. These results suggest that selective antagonism of the NMDA or AMPA/kainate receptors may be of therapeutic potential in AUD. |
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