Experiments in Molecular Subtype Recognition Based on Histopathology Images

• Autoři: BUDINSKÁ Eva; BOSMAN Fred; POPOVICI Vlad
• Rok publikování: 2016
• Druh: Článek ve sborníku
• Konference: 2016 IEEE 13TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI)
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=7493474
• Doi: https://doi.org/10.1109/ISBI.2016.7493474
• Obor: Informatika
• Klíčová slova: colon cancer; histopathology imaging; classification; gastrointestinal tract
• Popis: Molecular subtypes have been recently derived for various types of cancer, in an attempt to characterize the inter-tumoral heterogeneity. In this work we explore the possibility of constructing predictors for molecular subtypes based on histopathology images. For this, we introduce a novel 2-level bag-of-features method and we apply it to a collection of colorectal cancer samples. The resulting image features capture some relevant tumor morphology patterns and led to a classifier performing similarly to one constructed from features annotated by an expert pathologist. The significance of our results extends beyond subtype prediction since they demonstrate a possible approach to multimodal (histopathology and molecular) data mining and biomarker identification.

Související projekty

• Computational framework for joint analysis of histopathology images and gene expression data