All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts

Investor logo
Investor logo
Investor logo
Investor logo

Warning

This publication doesn't include Institute of Computer Science. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors

SARYCHEVA Tatyana Vladimirovna CAPKOVA Nadezda PAJAK Andrzej MALYUTINA Sofia TAMOSIUNAS Abdonas BOBÁK Martin PIKHART Hynek

Year of publication 2022
Type Article in Periodical
Magazine / Source Nature Scientific Reports
MU Faculty or unit

Faculty of Science

Citation
Web https://www.nature.com/articles/s41598-022-17261-5
Doi http://dx.doi.org/10.1038/s41598-022-17261-5
Keywords PULMONARY-FUNCTION; INCREASED RISK; FEV1; SPIROMETRY; PREDICTOR; INDIVIDUALS; ASSOCIATION; OUTCOMES; VALUES
Attached files
Description It is unclear whether the dose-response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean age of 59 +/- 7.3 years from population registers in Czech, Polish, Russian and Lithuanian urban centres. The baseline survey in 2002-2005 included 36,106 persons of whom 24,944 met the inclusion criteria. Cox proportional hazards models were used to estimate the dose-response relationship between lung function defined as FEV1 divided by height cubed and all-cause and cardiovascular mortality over 11-16 years of follow-up. Mortality rate increased in a dose-response manner from highest to lower FEV1/height(3) deciles. Adjusted hazard ratios (HR) of all-cause mortality for persons in the 8th best, the 5th and the worst deciles were 1.27 (95% CI 1.08-1.49), 1.37 (1.18-1.60) and 2.15 (1.86-2.48), respectively; for cardiovascular mortality, the respective HRs were 1.84 (1.29-2.63), 2.35 (1.67-3.28) and 3.46 (2.50-4.78). Patterns were similar across countries, with some statistically insignificant variation. FEV1/height(3) is a strong predictor of all-cause and cardiovascular mortality, across full distribution of values, including persons with preserved lung function.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info