Colorectal Tumour Mucosa Microbiome Is Enriched in Oral Pathogens and Defines Three Subtypes That Correlate with Markers of Tumour Progression

Investor logo
Investor logo
Investor logo

Warning

This publication doesn't include Institute of Computer Science. It includes Faculty of Science. Official publication website can be found on muni.cz.
Authors

ZWINSOVÁ Barbora PETROV Viacheslav HRIVŇÁKOVÁ Martina SMATANA Stanislav KOSEČKOVÁ MICENKOVÁ Lenka KAZDOVÁ Natálie POPOVICI Vlad HRSTKA Roman ŠEFR Roman BENCSIKOVÁ Beatrix ZDRAŽILOVÁ DUBSKÁ Lenka BRYCHTOVÁ Veronika NENUTIL Rudolf VÍDEŇSKÁ Petra BUDINSKÁ Eva

Year of publication 2021
Type Article in Periodical
Magazine / Source Cancers
MU Faculty or unit

Faculty of Science

Citation
Web text článku
Doi http://dx.doi.org/10.3390/cancers13194799
Keywords colorectal cancer; 16S rRNA gene; tumour microbiome; microbial subtypes
Attached files
Description Dysbiosis of the gut microbiome may contribute to the heterogeneity of colorectal cancer from phenotypic, prognostic and response to treatment perspectives. We analysed CRC microbiome by 16S rRNA gene sequencing of paired tumour mucosa, adjacent visually normal mucosa and stool swabs of 178 patients with stage 0–IV CRC. We observed that tumour mucosa is dominated by pathogenic bacteria of oral origin and proposed a CRC tumour microbiome subtyping system. The subtypes and tumour mucosa genera were associated with prognostic clinical covariates (tumour grade, localisation, TNM, BRAF mutation and MSI). In contrast, changes in the stool microbiome were associated with lymph node involvement and the presence of synchronous metastases. We discovered new associations between microorganisms and CRC and clinical parameters. Our study represents a step forward in understanding the role of the microbiome and its interactions with factors involved in tumour progression, and it opens novel avenues for exploring new treatments and biomarkers.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info