Generation of humanized bone marrow-like niche for leukemic xenotransplantation in mice: comparison of biomaterials

Herudková,  Zdeňka; Sokol,  Filip; Vlažný,  Jakub; Matulová,  Květoslava; Křen,  Leoš; Repko,  Martin; Vojtová,  Lucy; Nováková,  Zuzana; Ráčil,  Zdeněk; Mayer,  Jiří; Čulen,  Martin

Generation of humanized bone marrow-like niche for leukemic xenotransplantation in mice: comparison of biomaterials

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Authors	HERUDKOVÁ Zdeňka SOKOL Filip VLAŽNÝ Jakub LIŠKOVÁ Květoslava KŘEN Leoš REPKO Martin VOJTOVÁ Lucy ŠUSTKOVÁ Zuzana RÁČIL Zdeněk MAYER Jiří ČULEN Martin
Year of publication	2020
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Engraftment of leukemic cells in immunodeficient mice can be improved by incorporation of a humanized bone marrow microenvironment, formed by mesenchymal stromal cells (MSC) and a suitable biomaterial. Various biomaterials ranging from ceramic calcium phosphate to extracellular matrix (ECM) gels were reported so far but their comparison is lacking.
Related projects:	CEITEC 2020