Project information
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
- Project Identification
- NU22-02-00348
- Project Period
- 5/2022 - 12/2025
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
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Faculty of Science
- Mgr. Jiří Pacherník, Ph.D.
- Mgr. Stanislava Sladeček, Ph.D.
- Bc. Patrik Šmahlík
- Cooperating Organization
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University Hospital Brno-Bohunice
- Responsible person doc. MUDr. Tomáš Novotný, Ph.D.
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 49
2025
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A variant in the SCN5A gene, M135V-Nav1.5, associated with idiopathic ventricular fibrillation: clinical, genetic, and functional data
Year: 2025, type: Conference abstract
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Arytmogenní dopad varianty Y4734C v genu RYR2 asociované s idiopatickou fibrilací komor: analýza využívající pacient-specifické kardiomyocyty
Year: 2025, type: Conference abstract
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Effect of sex hormones on patient-specific cardiomyocytes of a female patient with catecholaminergic polymorphic ventricular tachycardia
Year: 2025, type: Conference abstract
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Functional analysis in three probands suffering from “true” idiopathic ventricular fibrillation
Year: 2025, type: Conference abstract
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Functional impact of hERG variants S1021Qfs*98 and A228V associated with idiopathic ventricular fibrillation
Year: 2025, type: Conference abstract
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Multielectrode array technique as an effective tool for studying cardiac electrophysiology and its changes in pathology: problematic aspects of analysis
Year: 2025, type: Appeared in Conference without Proceedings
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Pacient s idiopatickou fibrilací komor a dvěma variantami v genu KCNH2: klinická, genetická a funkční analýza
Year: 2025, type: Conference abstract
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Reassessment of mechanical restitution in guinea pig cardiomyocytes through refined computational modelling
Nature Scientific Reports, year: 2025, volume: 15, edition: 1, DOI
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Srovnání elektrické aktivity 2D a 3D modelů pacient-specifických kardiomyocytů diferencovaných z lidských indukovaných pluripotentních buněk
Year: 2025, type: Conference abstract
2024
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Aminophylline at clinically relevant concentrations affects inward rectifier potassium current in healthy porcine and failing human cardiomyocytes in a similar manner
Biomedicine & Pharmacotherapy, year: 2024, volume: 181, edition: December 2024, DOI