Comment on "Computational Model for Predicting Experimental RNA and DNA Nearest-Neighbor Free Energy Rankings"

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Authors	ŠPONER Jiří MORGADO Claudio A SVOZIL Daniel
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Journal of Physical Chemistry B
MU Faculty or unit	Central European Institute of Technology
Citation
web	http://pubs.acs.org/doi/abs/10.1021/jp300659f?mi=0&af=R&pr...
Doi	https://doi.org/10.1021/jp300659f
Field	Biophysics
Keywords	ACID BASE-PAIRS; STACKING ENERGIES; STABILITY; PARAMETERS; STEPS
Attached files	JPC-B-Morgano.pdf
Description	Recently, Johnson et al.1 reported interesting quantumchemical computations on base stacking and base pairing energies in B-DNA and A-RNA. They deduced that “there most definitely is a quantitative correlation between the quantum mechanical gas-phase stacking data and nucleic acid stability”. Such conclusion is, in our opinion, too optimistic and oversimplified. We identified several issues questioning the validity of this statement.
Related projects:	CEITEC - Central European Institute of Technology Centrum biologie RNA