In Silico Engineering of Proteins that Recognize Small Molecules

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Authors	MISHRA Sushil Kumar DEMO Gabriel KOČA Jaroslav WIMMEROVÁ Michaela
Year of publication	2012
Type	Chapter of a book
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Protein engineering is a rapidly evolving discipline, with much research currently focused on understanding the catalysis, specificity, stability, and folding of proteins, structure-function relationships and protein design principles. Engineered proteins are now successfully being used in biotechnology and in therapeutic settings. Advances in technology and genetic and chemical techniques have enabled a competitive edge in developing improved protein and peptide based therapeutics with reduced immunogenicity, improved safety and greater effectiveness.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs Lectins from human pathogens - structure, function, engineering Molekulární a strukturní biologie vybraných cytostatik. Od mechanických studií k chemoterapii rakoviny Enzymy metabolismu mannosidů v přípravě N-acetyl-mannosaminových struktur CEITEC - Central European Institute of Technology