Enhancement of psychostimulant effect and development of behavioural sensitisation to methamphetamine in mice by combined treatment with piracetam

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Authors	MÁCHALOVÁ Alena ŠLAIS Karel VRŠKOVÁ Dagmar ŠULCOVÁ Alexandra
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Activitas Nervosa Superior Rediviva
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	methamphetamine; piracetam; behavioural sensitisation; mice; open field test
Description	Piracetam in our experiment enhanced acute effects of methamphetamine as well as development of sensitisation to its stimulatory effects. Background of these pharmacological drug-drug interactions remains unclear. Although clinically piracetam itself shows minimal adverse effects and toxicity, its combination with methamphetamine could worsen the negative drug abuse consequences.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.