Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres

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Authors	NEČAS Alois PLÁNKA Ladislav SRNEC Robert CRHA Michal HLUČILOVÁ Jana KLÍMA Jiří STARÝ David KŘEN Leoš AMLER Evžen VOJTOVÁ Lucy JANČÁŘ Josef GÁL Petr
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Physiol. Res.
MU Faculty or unit	Faculty of Medicine
Citation
Field	Traumatology and orthopaedic surgery
Keywords	bone marrow mesenchymal stem cells;allogeneic;micropicking;articular cartilage
Description	It follows from the above-said that treatment of iatrogenic lesions of the surface of articular cartilage on femur condyles in miniature pigs after transplantation of mesenchymal stem cells in a composite scaffold based on collagen I containing micro- and nanofibers from chitosan resulted in filling of tissue defects in a hyaline type of cartilage. Lesions treated by implantation of scaffold alone or by micropicking were filled with fibrous cartilage with inferior macroscopic, histological and immunohistochemical parameters.
Related projects:	Využití nově syntetizovaných biomateriálů v kombinaci s kmenovými buňkami v léčbě chorob, které postihují lidské tkáně derivované z mesodermu: chrupavka, kost, vazy a menisky