Hyperintenzivní léze reagující na steroidy u pacienta s Creutzfeldt-Jakobovou nemocí

• Title in English: Steroid-Responsive Hyperintense Lesions in a Patient with Creutzfeldt-Jakob Disease
• Authors: SHEARDOVÁ Kateřina; MATĚJ R.; REKTOROVÁ Irena
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Ceska a slovenska neurologie a neurochirurgie
• MU Faculty or unit: Faculty of Medicine
• Field: Neurology, neurosurgery, neurosciences
• Keywords: Creutzfeldt-Jakob disease; magnetic resonance imaging; corticosteroids
• Description: Abstract: Typical hyperintense changes in the striata and cerebral cortices on T2-weighted (T2W), fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging (DWI) have been described in patients with Creutzfeldt-Jakob disease (CJD). We report the case of a 71-year-old woman with a definite autopsy-proven diagnosis of sporadic CJD Heidenhain variant with T2W and FLAIR hyperintense lesions in parietal and occipital cortex bilaterally on MRI, regressing after steroid administration despite progression of the disease.

Related projects

• The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.