Vztah progrese diabetické nefropatie a mortality k funkčnímu deficitu pentózového jako důsledku abnormálního metabolizmu thiaminu u DM

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Title in English	Relation between progression of diabetic nephropathy and mortality and.the functional deficiency of pentose phosphate cycle enzymes as a result of abnormality in thiamine status in diabetic patients
Authors	KRUSOVÁ Darja PÁCAL Lukáš KAŇKOVÁ Kateřina SVOJANOVSKÝ Jan TOMANDL Josef OLŠOVSKÝ Jindřich
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Aktuality v nefrologii
MU Faculty or unit	Faculty of Medicine
Citation
Field	Other medical specializations
Keywords	diabetic nephropathy; pentose phosphate cycle; thiamin
Description	The results support the role of functional thiamine deficiency in the development of hyperglycaemia- related pathology. Limited intracellular availability of active TKT co-factor seems to be a dominant abnormality.
Related projects:	Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy