DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R

Slanina,  Jiří; Adámková,  Lenka; Koubíková,  Ludmila; Hammerová,  Jindřiška; Slaninová,  Iva

DEOXYSCHIZANDRIN AND GAMMA-SCHIZANDRIN RESTORE THE CYTOTOXIC ACTION OF DOXORUBICIN IN MULTI-DRUG RESISTANT LUNG CANCER CELLS COR-L23/R

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Authors	SLANINA Jiří ADÁMKOVÁ Lenka KOUBÍKOVÁ Ludmila HAMMEROVÁ Jindřiška SLANINOVÁ Iva
Year of publication	2010
Type	Chapter of a book
MU Faculty or unit	Faculty of Medicine
Citation
Description	We found that the lignans R-(+)-deoxyschizandrin and R,S-gamma-schizandrin restored the cytotoxic action of the MRP1 substrate doxorubicin to COR-L23/R cells at relatively non-toxic concentrations of the lignans. Deoxyschizandrin and gamma-schizandrin also showed the greatest propensity to enhance the accumulation of doxorubicin in drug resistant cells.
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