Metabolic ratio of dextromethorphan/dextrorphan in CYP2D6 phenotyping - identification of cut-off values in serum and corelation with urine levels

Juřica,  Jan; Zendulka,  Ondřej; Bartečková,  Eliška; Žourková,  Alexandra; Pindurová,  Eva; Zrůstová, Jana; Šulcová,  Alexandra

Metabolic ratio of dextromethorphan/dextrorphan in CYP2D6 phenotyping - identification of cut-off values in serum and corelation with urine levels

Warning

This publication doesn't include Institute of Computer Science. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	JUŘICA Jan ZENDULKA Ondřej BARTEČEK Richard ŽOURKOVÁ Alexandra FLODROVÁ Eva ZRŮSTOVÁ Jana ŠULCOVÁ Alexandra
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	The results of investigation of correlation of serum and urine dextromethorphan/dextrorphan metabolic ratio in CYP2D6 phenotyping were presented. Based on genetic analysis and values of MR, cutt off values (MRdem/dor) for separating extensive, poor and intermediate metabolizers were also identfied.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions. Vliv farmakogenetických a farmakokinetických faktorů na účinnost a bezpečnost terapie prvních epizod schizofrenie