Centrosome amplification as possible marker of myeloma cell precursors

Kryukov,  Fedor; Kryukova,  Elena Vladimirovna; Němec,  Pavel; Burešová,  Ivana; Smetana,  Jan; Grešliková,  Henrieta; Kupská,  Renata; Kuglík,  Petr; Hájek,  Roman

Centrosome amplification as possible marker of myeloma cell precursors

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Authors	KRYUKOV Fedor DEMENTYEVA Elena Vladimirovna NĚMEC Pavel BUREŠOVÁ Ivana SMETANA Jan GREŠLIKOVÁ Henrieta KUPSKÁ Renata KUGLÍK Petr HÁJEK Roman
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	In our study, we showed association of CA in B-cells with PCs hyperdiploidy. This fact relates to role of mitotic disruption in MM aneuploidy and cell carcinogenesis. In association with correlation between B-cells and PCs with CA, we suppose that B-cells with CA are part of myeloma genesis.
Related projects:	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies Úloha abnormalit chromozómu 1 a kaskády NF-kappaβ v patogenezi mnohočetného myelomu