Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status

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Title in English	Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status.
Authors	HUBLAROVÁ Pavla HRSTKA Roman ROTTEROVÁ Pavla ROTTER Leopold ČOUPKOVÁ Marie BADAL Vinay NENUTIL Rudolf VOJTĚŠEK Bořivoj
Year of publication	2009
Type	Article in Periodical
Magazine / Source	International Journal of Gynecologic Cancer
MU Faculty or unit	Faculty of Medicine
Citation
web	http://www.pubmed.gov
Field	Other medical specializations
Keywords	cervix; cervical intraepithelial neoplasia; HPV16; E6 gene; promoter methylation
Description	Human papillomavirus (HPV) infection is the most important risk factor for development of CIN and cervical cancer. We analyse HPV16 E6 gene promoter methylation. Incidence of HPV16 significantly differed (P<0.001,chi-square test of Pearson). Methylation was detected and statistical significant differencies were found (P<0.001; Pearsons chi-square test). Methylation of the E6 gene promoter is predictive biomarker for cervical cancer progression.
Related projects:	Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine