Efficacious but insidious: A retrospective analysis of fludarabine induced myelotoxicity using long term culture initiating cells in 100 follicular lymphoma patients

• Authors: JANÍKOVÁ Andrea; KOŘÍSTEK Zdeněk; VINKLÁRKOVÁ Jaroslava; PAVLÍK Tomáš; ŠTÍCHA Michal; NAVRÁTIL Milan; KRÁL Zdeněk; VÁŠOVÁ Ingrid; MAYER Jiří
• Year of publication: 2009
• Type: Article in Periodical
• Magazine / Source: Experimental Hematology
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: NON-HODGKIN-LYMPHOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; BLOOD PROGENITOR CELLS; ACUTE MYELOID-LEUKEMIA; PREVIOUSLY UNTREATED PATIENTS; IV INDOLENT LYMPHOMA; HIGH-DOSE THERAPY; BONE-MARROW; PHASE-II
• Description: Fludarabine has been recognized as effective treatment in patients with follicular lymphoma (FL), but can induce myelotoxicity of unknown mechanism. Fludarabine and procarbazine have a dramatic influence, especially on the most immature hematopoietic cells, mirrored in reduced numbers of LTC-IC. This finding is consistent with clinical observations (poor mobilization after fludarabine) and offers an insight into the mechanism of fludarabine-induced myelotoxicity.

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