Growth Differentiation Factor-15 secreted by prostate cancer cells inhibits differentiation of osteoclasts

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Authors	VAŇHARA Petr LINCOVÁ Eva SOUČEK Karel ŠMARDA Jan
Year of publication	2009
Type	Article in Proceedings
Conference	the FEBS Journal, 256, Suppl. 1
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	GDF-15; osteoclats; prostate cancer
Description	Prostate cancer is a common disease in industrial countries. Prostate tumors preferentially disseminate to bones and induce significant rearrangement of the bone architecture. T The aim of this study is to characterize effects of growth differentiation factor-15 (GDF-15) secreted by prostate cancer cells on the osteoclastic differentiation pathway. This study documents that GDF-15 both as purified substance and as unpurified product secreted by prostate cancer cells strongly interferes with differentiation of osteoclasts by inhibiting expression and activity of NFkB and c-Fos.
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