The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.

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Authors	BRYJA Vítězslav ANDERSSON Emma R. SCHAMBONY Alexandra ESNER Milan BRYJOVÁ Lenka BIRIS Kristin K. HALL Anita C. KRAFT Bianca ČAJÁNEK Lukáš YAMAGUCHI Terry P. BUCKINGHAM Margaret ARENAS Ernest
Year of publication	2008
Type	Article in Periodical
Magazine / Source	: Molecular Biology of the Cell
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	non-canonical Wnt signalling; Lrp5/6; mouse; Xenopus
Description	Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo.
Related projects:	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies EMBO Young Investigator Programme