The association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children

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Authors	IZAKOVIČOVÁ HOLLÁ Lydie MUSILOVÁ Kristína VOKURKA Jan KLAPUŠOVÁ Lucie PANTŮČKOVÁ Pavla KUKLETOVÁ Martina KUKLA Lubomír ZNOJIL Vladimír
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Acta Odontologica Scandinavica
MU Faculty or unit	Faculty of Medicine
Citation
Field	ORL, ophthalmology, stomatology
Keywords	cytokine; gene; gingivitis; PCR; polymorphism
Description	The proinflammatory cytokine interleukin-6 (IL-6) is a key regulator of the host response to microbial infection and major modulator of extracellular matrix catabolism and bone resorption. The aim of this case-control study was to test differences between children with and without gingivitis in distribution of IL-6 alleles at positions -174, -572, and -597 and their haplotypes. Our results indicate that the three promoter polymorphisms in the IL-6 gene act in a cooperative fashion and suggest that IL-6 haplotypes could play a role in the pathogenesis of gingivitis in Caucasian children.
Related projects:	Dental research centre Analýza polymorfizmů v genech prozánětlivých a remodelačních faktorů ve vztahu k imunitní reakci a klinickému stavu pacientů s parodontitidou Stav orálního zdraví u dětí sledovaných v programu ELSPAC Brno