Srovnání účinků citalopramu a vybraných antiepileptik v modelu sociálního stresu u myší

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Title in English	Comparison of the effects of citalopram and those of selected antiepileptic drugs in the mouse model of social stress
Authors	PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra
Year of publication	2005
Type	Article in Periodical
Magazine / Source	Československá fyziologie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	social stress; citalopram; antiepileptic; antidepressant; mice; animal model
Description	To compare behavioural effects of valproate, carbamazepine, lamotrigine, gabapentine and citalopram we used the mouse model of social stress based on the suppression of locomotor-exploratory activity in a male group-housed mouse repeatedly defeated in social interactions with an aggressive singly-housed partner. Antidepressants were shown to disinhibit the social defeat-induced supression of the locomotion in the open field test. Citalopram, valproate and carbamazepine exhibited similar antidepressant-like effects in this model of social stress, unlike lamotrigine and gabapentine.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions. Plasticity of Regulatory Mechanisms of the Central Nervous Systems