Interakce účinků extáze, metamfetaminu a kanabinoidů v animálních modelech

• Title in English: Interactions of the ecstasy, methamphetamine and cannabinoids effects in animal models
• Authors: LANDA Leoš; ŠLAIS Karel; KUČEROVÁ Jana; ŠULCOVÁ Alexandra
• Year of publication: 2006
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Repeated administration of MDMA elicited in mice in the open field test both development and expression of sensitization. Repeated pre-treatment by CB1 receptor agonist led to cross-sensitization to the MDMA challenge dose and, in contrary, repeated administration of CB1 receptor antagonist+MDMA suppressed this phenomenon. We did not confirm our hypothesis, that repeated administration of MDMA would sensitise to antiaggressive effects in the mice model of agonistic behaviour.

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