Stanovení diklofenaku a 4-hydroxydiklofenaku jako markeru metabolické aktivity CYP2C9

Juřica,  Jan; Tomandl,  Josef; Zendulková Zahradníková,  Lucia; Dostálek,  Miroslav; McCaskey Hadašová,  Eva

Stanovení diklofenaku a 4-hydroxydiklofenaku jako markeru metabolické aktivity CYP2C9

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Title in English	Determination of diclofenac and 4-hydroxydiclofenac as a probe substrate of CYP2C9
Authors	JUŘICA Jan TOMANDL Josef ZAHRADNÍKOVÁ Lucia DOSTÁLEK Miroslav HADAŠOVÁ Eva
Year of publication	2005
Type	Article in Proceedings
Conference	Sborník abstrakt 34. konference Syntéza a analýza léčiv- Nové směry ve výzkumu léčiv
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	Diclofenac; CYP2C9; determination
Description	Diclofenac 4-hydroxylation is commonly used for the CYP2C9 metabolic evaluation. A new rapid, simple and sensitive HPLC method for determination of diclofenac and 4-hydroxydiclofenac was developed.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems