Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice

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Authors	LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra HANESOVÁ Mariana
Year of publication	2004
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	behavioural sensitization; methamphetamine; memantine; open field test; mice
Description	Methamphetamine (MET) similarly to other psychostimulant drugs invokes during its repeated administration a significant increase in behavioural responses. This phenomenon is termed behavioural sensitization. There are various reports on involvement of N-methyl-D-aspartate (NMDA) receptor activity in the development and expression of behavioural sensitization, although results of them are rather controversial. Thus, the present study was designed to investigate a possible influence of NMDA receptor non-competitive antagonist memantine (MEM) on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field test.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems