Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group: Synthesis, Characterization, and in Vitro Antitumor Activity against a Panel of Cisplatin-Resistant Cancer Cell Lines

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Authors	ŽÁK František TURÁNEK Jaroslav KROUTIL Aleš SOVA Petr MISTR Adolf POULOVÁ Anna MIKOLIN Petr ŽÁK Zdirad KAŠNÁ Andrea ZÁLUSKÁ Dana NEČA Jiří ŠINDLEROVÁ Lenka KOZUBÍK Alois
Year of publication	2004
Type	Article in Periodical
Magazine / Source	Journal Medicinal Chemistry
MU Faculty or unit	Faculty of Science
Citation
Field	Immunology
Keywords	Platinum(V) Complex with Adamantylamine as Nonleaving Amine Group
Description	Procedure of the synthesis is dedescribed for new platinum(V) drug LA-12 [(OC-6-43)-bis-(acetato)(1-adamantylamine)amminedichloroplatinum(IV)]. The X-ray diffraction analysis shows that the structure is created by molecules with octahedral arrangement of ligands around a platinum atom and contains one H2O molecule that is not a part of the coordination sphere of platinum.
Related projects:	Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles