Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells

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Authors	FAJKUS Jiří BORSKÝ Marek KUNICKÁ Zuzana KOVAŘÍKOVÁ Martina DVOŘÁKOVÁ Dana HOFMANOVÁ Jiřina KOZUBÍK Alois
Year of publication	2003
Type	Article in Periodical
Magazine / Source	Anticancer Research
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	telomerase regulation; human colon cells; butyrate; alternative splicing; flow cytometry
Description	Downregulation of telomerase activity and expression occurs in response to butyrate-induced differentiation in normal and carcinoma colon cells. Differential splicing of hTERT mRNA may be involved in faster loss of telomerase activity in normal cells with respect to malignant cells.
Related projects:	Development of new diagnostic teniques for oncology Genomes and their functions