Co-administration with cannabinoid receptro antagonist AM251 attenuates behavioural sensitization to methamphetamine antiaggressive effect in mice

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Authors	ŠULCOVÁ Alexandra LANDA Leoš
Year of publication	2003
Type	Article in Periodical
Magazine / Source	Behavioural Pharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	cannabinoid antagonist - AM251- methamphetamine - sensitiazation
Description	The sensitization to MET was clearly demonstrated in aggressive agonistic interactions while the pre-treatment with 5 MET doses of 1 mg/kg/day significantly potentiated the effects (inhibition of aggressive and disinhibition of locomotor activities measured) of all MET "challenge doses" (1 or 5 or 10 mg/kg) given after 5 days of withdrawal. In the same experimental design the cross-sensitization to MET was confirmed after the pre-treatment with 5 doses (0.5 mg/kg/day) of CAN, while in the present study, the co-administration of MET with cannabinoid receptor antagonist AM (0.5 mg/kg/day) suppressed the development of sensitization to MET antiaggressive effect but not to its stimulatory influence on locomotion.
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